HSP70 and HSP90 in neurodegenerative diseases
نویسندگان
چکیده
منابع مشابه
The Hsp70/Hsp90 Chaperone Machinery in Neurodegenerative Diseases
The accumulation of misfolded proteins in the human brain is one of the critical features of many neurodegenerative diseases, including Alzheimer's disease (AD). Assembles of beta-amyloid (Aβ) peptide-either soluble (oligomers) or insoluble (plaques) and of tau protein, which form neurofibrillary tangles, are the major hallmarks of AD. Chaperones and co-chaperones regulate protein folding and c...
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ژورنال
عنوان ژورنال: Neuroscience Letters
سال: 2020
ISSN: 0304-3940
DOI: 10.1016/j.neulet.2019.134678